Self-collection of vaginal specimens for HPV testing in cervical cancer prevention (MARCH): a community-based randomised controlled triall

By Maggie Sullivan Moderator | 22 Nov, 2011

Posted in the GHDonline Endemic Non-Communicable Disease Community by Ziad El-Khatib on 14 Nov 2011. Feel free to join their group and respond.

I am sharing a recent paper by Lazcano-Ponce from Mexico. An elegant randomized trial, that compared HPV DNA testing, self-collected vaginal samples, vs. cervical cytology.
HPV DNA testing was much more sensitive than cytology. However it has lower positive predictive value.
It is a very relevant topic for limited-resource settings, where there is no cytology infrastructure.

I would be curious to know about the NCD community feedback on the questions of going for HPV DNA testing vs. cytology.
What can be the consequences for the health care system to (1) invite more women for screening but they might not come back for follow-up or (2) wait until they present with invasive cancer?

Thank you,

Attached resource: Self-collection vaginal samples in limited-resource settings


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